Neural SMG7 deficiency induces autism-like behaviours via PKD1 upregulation - PubMed
3 hours ago
- #PKD1 upregulation
- #Smg7 deficiency
- #autism-like behaviors
- Neural Smg7 deficiency causes autism-like behaviors in mice, including social deficits, repetitive actions, anxiety, and cognitive impairments.
- The autism-like phenotypes are associated with increased neuronal excitability and higher dendritic spine density in specific brain regions.
- Smg7 deletion leads to upregulation of PKD1, an NMD target, which contributes to the observed behavioral and neuronal changes.
- Knocking down PKD1 in the hippocampus and medial prefrontal cortex rescues social deficits in Smg7-deficient mice, highlighting a potential therapeutic target.