Activity-dependent protein synthesis in neurons requires microglial-metabolic coupling - PubMed
2 hours ago
- #microglia
- #brain metabolism
- #neuroimmunology
- Activity-dependent protein synthesis in neurons is essential for long-lasting synaptic plasticity and memory.
- Microglia are required for metabolic coupling between endothelial cells, astrocytes, and neurons to fuel this protein synthesis.
- Increased metabolic demand stimulates microglia to secrete CYR61, enhancing glucose transporter expression in brain vasculature.
- Depleting microglia or blocking CYR61 signaling reduces metabolic fluxes and neuronal protein synthesis.
- The study defines a neuroimmune metabolic circuit necessary for on-demand protein synthesis in the mouse motor cortex.