Inflammatory bowel disease and renal disorders: from clinical associations to shared mechanisms and management strategies - PubMed
2 days ago
- #Gut-Kidney Axis
- #Systemic Inflammation
- #Inflammatory Bowel Disease
- Inflammatory bowel disease (IBD) is strongly associated with renal conditions like chronic kidney disease, glomerulonephritis, and nephrolithiasis.
- Dysbiosis, intestinal barrier breakdown, and altered microbial metabolites (e.g., TMAO and SCFAs) drive systemic inflammation leading to renal injury.
- Intestinal lymphatic dysfunction acts as a key intermediary, creating a self-reinforcing loop with pro-inflammatory mediators worsening kidney damage.
- Shared mechanisms include IL-11-driven fibrosis, GSDMD-mediated pyroptosis, and free light chain toxicity, offering therapeutic targets.
- Vigilant renal monitoring in IBD and managing drug-induced nephrotoxicity are crucial, with therapies targeting microbiota or lymphatic function.