Developmental chronology of mouse embryo from 2-cell stage through birth - PubMed
3 hours ago
- #embryonic development
- #single-cell atlas
- #gene expression
- The study introduces the mouse developmental Cell and Lineage Atlas (mdCLA), which enhances temporal resolution and depth compared to existing atlases, covering 37 time points from E1.5 to E19.0 with about 2 million cells.
- Key findings include divergent gene expression in metanephric progenitors, with late-stage populations showing upregulated pathways for epithelial differentiation and immune response, and an accelerated epithelium-specific differentiation process after E14.5.
- Validation of transcription factors, such as Tub, revealed functional impacts; ablation in pituitary epithelium reduced follicle-stimulating hormone-producing cells, leading to postnatal obesity in mice.
- The mdCLA serves as a comprehensive reference for understanding mammalian embryogenesis, providing insights into cell types, gene expression, and developmental mechanisms throughout embryogenesis.