NUSAP1 mediates enzalutamide resistance in prostate cancer via Wnt/β-catenin signalling-dependent regulation of AR and AR-V7 - PubMed
3 hours ago
- #enzalutamide resistance
- #Wnt/β-catenin signalling
- #NUSAP1
- NUSAP1 overexpression is linked to enzalutamide resistance in prostate cancer.
- Knockdown of NUSAP1 reduces proliferation, migration, and invasion in resistant cells and increases sensitivity to enzalutamide.
- NUSAP1 activates Wnt/β-catenin signalling, promoting β-catenin nuclear translocation and enhancing AR and AR-V7 activity.
- Bioinformatics analysis identifies NUSAP1 as a prognostic gene associated with survival outcomes in prostate cancer.
- Targeting NUSAP1 could be a therapeutic strategy to overcome enzalutamide resistance in castration-resistant prostate cancer.