Pathophysiology of pregnancy-associated acute kidney injury - PubMed
3 hours ago
- #Pathophysiology
- #Maternal-fetal health
- #Pregnancy-associated acute kidney injury
- Pregnancy-associated acute kidney injury (PrAKI) significantly impacts maternal and fetal health globally, especially in low- and middle-income countries.
- PrAKI occurs due to pregnancy-specific factors like hemodynamic changes, immune adjustments, and placental interactions, reducing renal reserve.
- Key causes include hemodynamic vulnerability, placental ischemia releasing antiangiogenic factors (e.g., sFlt-1), immune dysregulation, and maternal comorbidities.
- PrAKI leads to long-term risks such as chronic kidney disease, cardiovascular issues, and fetal complications like growth restriction and prematurity.
- Understanding pathophysiology aids in diagnostics and treatments, including angiogenic biomarkers and targeted hemodynamic strategies, with future research focusing on predictors and global studies.