Phenotyping of pulmonary arterial hypertension associated with congenital heart disease using latent class analysis: insights from a national prospective registry - PubMed
4 hours ago
- #Congenital Heart Disease
- #Pulmonary Arterial Hypertension
- #Phenotyping
- PAH-CHD displays significant heterogeneity, challenging conventional classification systems.
- Latent class analysis identified four phenogroups each in pre- and post-tricuspid shunt subsets.
- Phenogroups exhibit distinct clinical profiles, survival rates, and responses to targeted therapies.
- Specific subgroups benefit uniquely from combination therapy, while others show attenuated treatment responses.
- LCA-based phenotyping offers a novel, data-driven approach for risk stratification and personalized management.