Cardiolipin preserves Treg metabolic fitness and immune homeostasis in the gut - PubMed
5 hours ago
- #Treg cells
- #cardiolipin metabolism
- #gut inflammation
- Cardiolipin is crucial for maintaining the metabolic fitness of regulatory T (Treg) cells, helping to preserve immune homeostasis in the gut.
- Deleting the cardiolipin-synthesizing enzyme PTPMT1 in T cells impairs Treg function, leading to increased susceptibility to colitis in mice without causing dysbiosis.
- Pathobiont infections worsen gut inflammation in mice lacking cardiolipin, indicating that cardiolipin deficiency exacerbates inflammatory responses.
- The absence of cardiolipin triggers a maladaptive integrated stress response in Treg cells, which can be reversed through pharmacological or genetic interventions to restore gut homeostasis.
- Barth syndrome, a genetic disorder with severe cardiolipin deficiency, shows similar gastrointestinal symptoms and T cell imbalances, reinforcing the role of cardiolipin in gut immunity.