Cardiovascular-kidney-metabolic (CKM) syndrome - PubMed
4 hours ago
- #CKM syndrome
- #Cardiovascular disease
- #Chronic kidney disease
- Cardiovascular-kidney-metabolic (CKM) syndrome links metabolic conditions like obesity, diabetes, and fatty liver disease with chronic kidney and cardiovascular diseases.
- Its prevalence is high and increasing, influenced by social determinants of health, individual behaviors, genetics, and epigenetics.
- Pathophysiology involves insulin resistance, inflammation, oxidative stress, and vascular dysfunction.
- Urinary albumin:creatinine ratio is a cost-effective biomarker for identifying and monitoring CKM syndrome.
- Prevention strategies include healthy behaviors (diet, activity, sleep, stress management) across the lifespan, along with established and emerging drugs offering renal and cardiac protection.
- Disease remission may be achievable with appropriate interventions.