Fenofibrate alleviates the brain edema after traumatic brain injury by enhancing endothelial OXPHOS - PubMed
3 hours ago
- #Fenofibrate
- #Traumatic Brain Injury
- #PPARα
- Fenofibrate (FFB) alleviates brain edema after traumatic brain injury (TBI) by enhancing blood-brain barrier integrity in a mouse model.
- FFB activates PPARα, enhances mitochondrial oxidative phosphorylation (OXPHOS) in endothelial cells, reducing oxidative stress and apoptosis.
- Mechanism confirmed via endothelial-specific PPARα knockout mice, identifying PPARα-dependent energy metabolism enhancement as a therapeutic strategy for TBI-induced edema.