CD300ld on pathologically activated neutrophils promotes tumor immune suppression by binding phosphatidylserine on CD8+ T cells - PubMed
3 days ago
- #tumor immune suppression
- #CD300ld phosphatidylserine
- #neutrophil CD8 T cell interaction
- CD300ld on pathologically activated neutrophils (PMN-MDSCs) binds phosphatidylserine on CD8+ T cells to mediate contact-dependent immunosuppression.
- Blocking the CD300ld-PS interaction with neutralizing antibodies reduces tumor immune evasion and synergizes with anti-PD1 therapy.
- Mice with mutant CD300ld lacking PS-binding capacity show reduced immunosuppressive activity, highlighting a targetable checkpoint pathway.