Comprehensive biochemical and radiological assessment of clinical characterization pertaining to bilateral adrenal masses: a multi-center cross-sectional investigation - PubMed
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- #adrenal adenoma
- #radiological assessment
- #bilateral adrenal masses
- The study retrospectively analyzed 1250 patients with bilateral adrenal masses from 2010-2025 across 17 endocrine centers in Turkey.
- Most patients (62.3%) had nonfunctioning adenomas, while others were diagnosed with autonomous cortisol secretion (19.9%), Cushing's syndrome (6.6%), or primary aldosteronism (11.2%).
- Biochemical parameters like basal cortisol, ACTH, and dexamethasone-suppressed cortisol levels differed significantly among diagnostic groups.
- Radiologically, adenomas were most common (92.3%), with 84.6–88% showing Hounsfield Units ≤10 on CT, indicating lipid-rich adenomas, and MRI confirmed this in 89% of cases evaluated.
- No significant correlation was found between clinical diagnosis and Hounsfield Unit values of adrenal masses.