SIRT6 overexpression counteracts chromatin aging in the male murine liver - PubMed
3 days ago
- #chromatin
- #aging
- #SIRT6
- Aging in the male murine liver is linked to increased chromatin accessibility, inflammation, and metabolic decline.
- SIRT6 overexpression reverses age-related chromatin changes, reducing inflammation and enhancing metabolic function.
- ETS family members are enriched in regions with increased accessibility during aging, while liver-enriched transcription factors are found in regions with reduced accessibility.
- H3K9ac, but not H3K56ac, is associated with increased chromatin accessibility in aging, and SIRT6 can reverse this effect.
- AAV-mediated SIRT6 overexpression in aged male mice rejuvenates chromatin accessibility to a youthful state.