RNA helicase DHX29 controls the translation of transcription factors involved in germinal center response and plasma cell differentiation in mice - PubMed
3 hours ago
- #RNA helicase
- #plasma cell differentiation
- #translational control
- RNA helicase DHX29 is identified as a critical regulator of plasma cell differentiation through a CRISPR/Cas9 screen.
- Mice with B-cell-specific deletion of DHX29 show impaired germinal center formation and antibody production.
- DHX29 promotes translation of Tcf3 and Tle3 mRNAs by binding to their 5' UTRs.
- DHX29-deficient B cells fail to switch to IgG1 and differentiate into plasma cells, though proliferation is normal.
- Ectopic expression of TCF3 and TLE3 restores plasma cell differentiation in DHX29-deficient cells.