Species-specific roles of SP1 in bovine and human embryonic genome activation and early embryonic development - PubMed
3 hours ago
- #Preimplantation development
- #Embryonic genome activation
- #SP1 transcription factor
- Embryonic genome activation (EGA) initiates the embryonic program and transitions to first lineage specification.
- Single-cell RNA-seq on bovine embryos shows major EGA starts asynchronously at the 8-cell stage.
- SP1, a transcription factor activated during minor EGA, has motifs enriched in accessible chromatin during major EGA in bovine and human embryos.
- SP1 deficiency causes morula arrest in bovine embryos and impairs EGA in human embryos.
- Multiomics analysis reveals SP1 promotes early lineage gene expression by modulating chromatin states in bovine and targets key EGA genes in human embryos.
- The study highlights conserved and species-specific roles of SP1 in EGA and early mammalian development.