Porcine Rotavirus NSP4 Inhibits Type I Interferon Production via NRBF2-Mediated Autophagic Degradation of MDA-5 - PubMed
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- #innate immunity
- #rotavirus
- Porcine rotavirus (PoRV) nonstructural protein 4 (NSP4) suppresses type I interferon (IFN-I) production and related antiviral immune responses.
- NSP4 promotes the autophagic degradation of melanoma differentiation-associated gene 5 (MDA-5) via nuclear receptor binding factor 2 (NRBF2), inhibiting IFN-I signaling.
- Mechanism includes reducing IFN-β promoter activity, phosphorylation of IRF3, and transcription of interferon-stimulated genes (ISGs).
- Findings validated in piglet intestinal organoid models, highlighting a novel immune evasion strategy for rotavirus.