Clinical Efficacy and Risks of Clonidine Infusion for Sedation and Analgesia: A Narrative Review - PubMed

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Clonidine is an α2 adrenergic receptor agonist used since 1966 for various purposes including as an antihypertensive, sedative, and analgesic.
It reduces sympathetic outflow and norepinephrine release, leading to pain modification and sedation via the dorsal horn and locus coeruleus.
Clonidine infusions are used perioperatively to reduce opioid requirements and treat both nociceptive and neuropathic pain post-surgery.
There is a lack of research on clonidine's isolated efficacy and risks when used alone, with gaps in comparing continuous vs. non-continuous infusion effects.
Future studies are needed to evaluate clonidine's performance and potential as a standalone therapy for sedation and analgesia.

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