Implications of ferritinophagy in cardiovascular diseases and its pharmacological modulation: underlying mechanisms and clinical translation strategies - PubMed
2 hours ago
- #NCOA4
- #Ferritinophagy
- #Cardiovascular Diseases
- Ferritinophagy is a process mediated by NCOA4 that regulates ferritin degradation and iron homeostasis.
- It plays a dual role in cardiovascular diseases, being essential for iron supply but harmful when excessive, leading to oxidative stress and ferroptosis.
- Excessive ferritinophagy contributes to conditions like myocardial ischemia-reperfusion injury, atherosclerosis, and diabetic cardiomyopathy.
- Pharmacological strategies to modulate ferritinophagy include direct inhibition via NCOA4 siRNA and lysosomal inhibitors, and indirect methods like ferroptosis inhibitors.
- Clinical translation faces challenges in tissue specificity, drug delivery efficiency, and long-term safety, with future directions focusing on organ-specific targeting and combination therapies.