Decoding Human Longevity: Genetic and Molecular Insights from Accelerated to Successful Ageing - PubMed
a day ago
- #Aging Mechanisms
- #Longevity Genetics
- #Centenarian Studies
- Aging is a heterogeneous process influenced by genetic, epigenetic, and environmental factors.
- Genetic models of accelerated aging reveal mechanisms behind premature functional decline.
- Studies of exceptionally long-lived individuals identify variants linked to resilience and stress adaptation.
- The review examines genetic and molecular mechanisms across the spectrum from progeroid syndromes to centenarians.
- Emerging pathways implicated in successful aging include hypoxic adaptation, transcriptional and chromatin regulation, autophagy, and metabolic reprogramming.
- Epigenetic clocks are discussed as tools for assessing biological aging, highlighting their strengths and limitations.