Curcumin as a multi-target therapy for osteoarthritis in rats: a systematic review and meta-analysis - PubMed
2 hours ago
- #meta-analysis
- #curcumin
- #osteoarthritis
- Curcumin significantly improves osteoarthritis-related outcomes in rats, including reduced OARSI scores, knee diameter, and apoptotic chondrocytes.
- It enhances antioxidant defense by increasing SOD activity and suppresses inflammation via the TLR4/NF-κB pathway, lowering pro-inflammatory cytokines like TNF-α and IL-6.
- Curcumin preserves cartilage metabolism by boosting type II collagen and decreasing markers of degradation such as MMP-13 and COMP.
- The findings suggest curcumin's multi-target effects make it a promising candidate for clinical translation in osteoarthritis management.
- Future research should focus on standardized methodologies to further explore curcumin's mechanisms and optimize therapeutic potential.