Two-dimensional HRS condensates drive the assembly of flat clathrin lattices on endosomes - PubMed
3 hours ago
- #endosome assembly
- #HRS condensates
- #clathrin lattices
- HRS protein forms two-dimensional condensates on membranes, facilitating flat clathrin lattice assembly.
- The flat clathrin structures observed on endosomes are formed at sub-micromolar HRS concentrations, matching in vivo levels.
- Cholesterol enhances HRS recruitment and phase separation on membranes, promoting cargo sorting through a positive feedback loop.