A systematic review of pregnancy outcomes and management in polycystic ovary syndrome - PubMed
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- #Polycystic Ovary Syndrome
- #Pregnancy Management
- #Adverse Pregnancy Outcomes
- PCOS affects 5-20% of reproductive-age women and accounts for 70-90% of anovulatory infertility.
- PCOS significantly increases risks of adverse pregnancy outcomes, including early pregnancy loss, gestational diabetes, and pre-eclampsia.
- Hyperandrogenism, insulin resistance, and obesity drive the pathophysiology of PCOS-related complications.
- Letrozole is superior for ovulation induction, and metformin provides metabolic benefits in PCOS pregnancies.
- Nuanced lifestyle interventions are preferred over simple weight-loss models.
- Emerging research into immune-metabolic pathways, such as Interleukin-22, suggests novel therapeutic directions.
- Recognizing PCOS as a high-risk obstetric condition is crucial.
- Early metabolic screening integrated into standard care improves maternal and neonatal outcomes.