Effects of inhaled nitric oxide on ventilation/perfusion mismatch assessed by electrical impedance tomography in intubated patients with moderate-to-severe ARDS: a prospective physiological study - Pu
4 hours ago
- #EIT
- #Nitric Oxide
- #ARDS
- Inhaled nitric oxide (iNO) was studied in a randomized controlled trial of 40 intubated patients with moderate-to-severe ARDS.
- The iNO group showed significantly improved ventilation-perfusion (V/Q) matching at 24 hours, with reductions in EIT-measured dead space and shunt.
- Gas exchange improved with iNO, evidenced by a greater increase in PaO2/FiO2 ratio and decrease in physiological shunt compared to the control group.
- iNO treatment also led to a greater reduction in pulmonary artery pressure.
- No significant differences were found in inflammatory biomarkers or safety parameters between groups.
- The study supports iNO's role in enhancing oxygenation via improved V/Q matching and suggests EIT could guide personalized therapy.