Proliferating toward sex: characterization of cell division of Toxoplasma gondii's pre-sexual stages - PubMed
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- #Toxoplasma gondii
- #cell division
- #pre-sexual stages
- Study characterizes cell division during pre-sexual differentiation of Toxoplasma gondii.
- Uses conditional depletion of transcription factors AP2XII-1 and AP2XII-2.
- Examines genome duplication, karyokinesis, cytokinesis, and daughter cell assembly.
- Provides spatial and temporal resolution of transitions between endodyogeny and endopolygeny.
- Identifies flexibility in division strategies from polyploid intermediates.
- Leverages expansion microscopy and stage-specific markers for analysis.
- Foundation for understanding sexual development and transmission mechanisms.