Clinical Features and Outcomes of Lean Metabolic Dysfunction Associated Steatotic Liver Disease with Increased Alcohol Intake - PubMed
3 hours ago
- #MetALD
- #Liver Disease Outcomes
- #Alcohol Use
- Study focuses on MetALD, a condition with liver steatosis from metabolic syndrome and alcohol, comparing 'lean' (BMI<25/<23 in Asians) vs 'non-lean' patients.
- Results from 98,076 veterans show lean MetALD linked to higher AUDIT-C scores and AST>ALT, while non-lean cases have more cardiometabolic factors and AST<ALT.
- Lean MetALD leads to a 28% increased risk of major adverse liver outcomes and an 82% higher all-cause mortality than non-lean MetALD, highlighting its severity.
- Findings suggest lean MetALD aligns with alcohol-associated liver disease patterns, needing specific treatments targeting alcohol use disorder.