MASLD as Complication of Diabetes - PubMed
3 hours ago
- #Type 2 Diabetes
- #MASLD
- #Liver Disease
- MASLD (metabolic dysfunction-associated steatotic liver disease) is the leading cause of chronic liver disease worldwide.
- MASLD is strongly linked to type 2 diabetes, with high prevalence rates of 65% in adults and 37% in children with diabetes.
- Diabetes-related hyperglycemia, hyperinsulinemia, and hyperlipidemia drive progression from simple steatosis to liver inflammation and fibrosis.
- MASLD is now considered a complication of diabetes, but screening and treatment are not yet routine in diabetes management.
- The article explores mechanisms in MASLD and diabetes, heterogeneity in MASLD pathophysiology, and risk stratification clusters.
- Sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide 1 receptor (co)agonists are recommended as first-line treatments due to their protective effects.