Neuroretinal Layer Thinning on OCT Imaging and Hemoglobin A1c in Youth With Type 1 Diabetes - PubMed
3 hours ago
- #Type 1 Diabetes youth
- #OCT imaging
- #Neuroretinal thinning
- Neuroretinal layer thinning, including retinal nerve fiber layer (RNFL) and ganglion cell plus inner plexiform layer (GCL+IPL), was observed via OCT imaging in youth with Type 1 Diabetes.
- The thinning was associated with higher hemoglobin A1c (HbA1c) levels, indicating a link between glycemic control and retinal neurodegeneration.
- The study found that neuroretinal thinning occurred even in youth without clinically apparent diabetic retinal disease (DRD), suggesting it precedes vascular changes.
- Among 578 eyes examined, 11.2% had mild DRD and 1.73% had moderate DRD, with moderate DRD showing non-significant associations with further thinning.
- The findings support using neuroretinal layer thinning as a potential biomarker for diabetic retinal neurodegeneration in youth with Type 1 Diabetes.