Emerging roles of ferroptosis in modulating the immune landscape of glial tumours - PubMed
3 hours ago
- #Ferroptosis
- #Glioma Immunology
- #Immune Evasion
- Ferroptosis, an iron-mediated lipid peroxidation cell death, influences immune-cell composition and function in glial tumors.
- It promotes microglia polarization and modulates CD8+ T cell cytotoxicity and regulatory T cell immunosuppression, affecting immune surveillance.
- Ferroptosis-driven mechanisms contribute to immune evasion and tumor evolution in gliomas.
- Combining ferroptosis-inducing agents with immunotherapies like checkpoint blockade may enhance immune responses for durable glioma control.