Amorfrutin-A, a membrane-targeting phytochemical active against multidrug-resistant Staphylococcus aureus: In vitro and in vivo activity and mechanism of action - PubMed
3 hours ago
- #Antimicrobial
- #Phytochemical
- #Drug Resistance
- Amorfrutin-A (AMF-A) shows strong antibacterial activity against Staphylococcus aureus with MIC values of 4-16 mg/L and no detected cytotoxicity.
- AMF-A disrupts bacterial membranes, eliminates biofilm and persister cells, and has a low resistance development frequency.
- The compound synergizes with antibiotics like daptomycin, piperacillin, and azithromycin, and demonstrates in vivo efficacy without toxicity in Galleria mellonella models.