What Breaks a Cell's Ribs Can Make It Stronger
3 days ago
- #Spindle Mechanics
- #Cell Division
- #Biophysics
- Cells divide by segregating chromosomes via the spindle apparatus, a microtubule structure that pulls chromosomes apart.
- Researchers used microneedles to physically manipulate mammalian spindles, revealing a self-repair mechanism under force.
- Spindle fibers break in the middle when pulled, but stabilize rather than unravel, akin to a melted rope end.
- Force application triggers the replacement of unstable microtubule components with more stable ones, reinforcing the spindle.
- This self-stabilization may explain how spindles withstand forces during cell division and could inspire engineered materials.