Structural dynamics of kappa opioid receptor interactions with β-arrestin 1 - PubMed
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- #GPCR
- #Structural Biology
- #Opioid Receptor
- Structure of kappa opioid receptor (KOR) with β-arrestin1 determined at 2.60 Å via cryo-EM.
- Phosphorylation sites and phospholipid-binding site enhance arrestin recruitment.
- Distinct structural features identified compared to other GPCR-βarr1 complexes.
- Differences from KOR-Nb39 and KOR-Gi1 complexes reveal signaling bias mechanisms.
- Conformational dynamics suggest allosteric pathway for arrestin entry/exit.