TREM2 modulates CXCL9:SPP1 polarity to influence macrophage-chondrocyte crosstalk and promote osteoarthritis progression - PubMed
2 hours ago
- #macrophage-chondrocyte crosstalk
- #CXCL9:SPP1 polarity
- #TREM2
- TREM2 modulates CXCL9:SPP1 polarity to influence macrophage-chondrocyte crosstalk and promote osteoarthritis progression.
- Joint injury is a major risk factor for osteoarthritis (OA), and CXCL9:SPP1 polarity regulates macrophage M1/M2 polarisation, affecting the joint microenvironment and cartilage metabolic balance.
- Bioinformatic analysis revealed TREM2+ macrophage overexpression in injured joints, linked to CS polarity and inflammation.
- In vivo studies showed TREM2 upregulation in OA model macrophages; TREM2 knockout promoted M2 polarisation, alleviated cartilage damage, and suppressed OA progression.
- In vitro, TREM2 knockdown in macrophages regulated CS polarity to enhance M2 and inhibit M1 polarisation, improving chondrocyte proliferation, migration, invasion, and reducing apoptosis.
- TREM2 upregulation in injured joint macrophages modulates CS polarity to control macrophage polarisation, inducing cartilage dysfunction and OA progression.