Channel Dysfunction as the Basis for Comorbidities in Multiple Sclerosis and Depression - PubMed
2 hours ago
- #Depression
- #Multiple Sclerosis
- #Ion Channels
- The comorbidity of depression and Multiple Sclerosis (MS) is linked to shared neurobiological mechanisms, not just psychological reactions.
- Ion channel dysfunction plays a central role in MS pathology, affecting neuronal excitability, synaptic transmission, and immune cell function.
- Demyelination and neuroinflammation alter ion channels like HCN, Kv7, and K2P, leading to neuronal hyperexcitability and altered network activity.
- Channels implicated in MS, such as TRPA1, ASIC1a, NMDA receptors, and 5-HT3 receptors, are also associated with affective regulation.
- Targeting ion channels offers novel therapeutic opportunities for addressing both neuroinflammation and depression in MS.