Challenge of diagnosing celiac disease in pediatric type 1 diabetes mellitus: lessons from long-term serological surveillance - PubMed
2 hours ago
- #serological screening
- #celiac disease
- #type 1 diabetes mellitus
- Children with type 1 diabetes mellitus (T1DM) have a higher risk of celiac disease (CD), often without typical symptoms.
- A 12-year retrospective study from Türkiye involved 206 pediatric patients with T1DM who underwent longitudinal CD screening.
- Among them, 11.6% showed tTG-IgA positivity, and 4.8% had biopsy-confirmed CD.
- ROC analysis identified an optimal tTG-IgA threshold of ≥7.3×ULN for CD diagnosis with high specificity but limited sensitivity.
- Some biopsy-confirmed CD cases had lower tTG-IgA levels (<3×ULN), indicating variability in serological markers.
- Continuous long-term monitoring and a multidimensional approach are recommended for accurate CD diagnosis in children with T1DM.