Deletion of Plasmodium yoelii Merozoite Surface Protein 8 Protects Mice From Lethal Blood-Stage Malaria and Is Associated With Enhanced Splenic CCL19-CCR7 Signaling - PubMed
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- #MSP8
- #malaria
- #CCL19-CCR7 signaling
- Deletion of Plasmodium yoelii Merozoite Surface Protein 8 (MSP8) protects mice from lethal blood-stage malaria.
- MSP8 immunization partially protects against lethal P. yoelii challenge and inhibits merozoite invasion in vitro.
- ΔMSP8 strain infection results in reduced parasitemia, attenuated splenomegaly, and self-resolving disease.
- MSP8 deficiency upregulates chemokine CCL19 and preserves receptor CCR7 in the spleen, increasing IFN-γ levels.
- Knockdown of CCR7 using shRNA partially reverses the survival advantage of ΔMSP8 infection, lowering IFN-γ and increasing mortality.
- Targeting MSP8 or enhancing CCL19-CCR7 signaling represents a strategy for malaria vaccines and host-directed interventions.