The microbiota-gut-brain axis: novel mechanisms and therapeutic frontiers in obesity and type 2 diabetes - PubMed
3 hours ago
- #microbiota-gut-brain axis
- #obesity
- #type 2 diabetes
- The microbiota-gut-brain axis (MGBA) is a bidirectional network connecting gut microbes to the central nervous system.
- Microbial messengers such as short-chain fatty acids, bile acids, neuroactive metabolites, and extracellular vesicles contribute to obesity and type 2 diabetes through neural, endocrine, and immune pathways.
- Dysregulation of the MGBA leads to hypothalamic dysfunction, adipose inflammation, incretin axis impairment, and β‑cell failure.
- The review discusses MGBA-targeted therapies and their translational challenges.