Mast cell score associates with wide-spread mast cell symptoms and comorbidities in patients with hEDS and HSD - PubMed
4 hours ago
- #MCAS Symptoms
- #hEDS/HSD
- #Mast Cell Score
- Researchers developed a mast cell (MC) score based on 11 self-reported MC-related conditions to assess MC symptoms in patients with hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD).
- In a study of 2,141 hEDS/HSD patients, 25% had high MC scores (≥5). Those with high scores reported more MCAS-specific symptoms like nausea and vomiting compared to low-score patients.
- High MC scores were associated with increased random blood IgE, tryptase, and major basic protein (MBP), but not elevated urinary MC markers or clinical blood tryptase.
- Patients with high MC scores showed nearly doubled rates of abuse or PTSD and reported more widespread symptoms/comorbidities overall.
- The MC score is a useful tool for evaluating widespread mast cell activity in hEDS, HSD, and potentially other patient groups.