Protective TMEM106B-rs3173615 delays age at onset in GRN mutation carriers - PubMed
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- #Age at onset
- #Genetic modifier
- #Frontotemporal dementia
- The study investigates how the coding variant TMEM106B-rs3173615 modulates age at onset, survival, and PGRN levels in GRN mutation carriers.
- Individuals with the protective genotype (GG) had an 80% reduced risk of FTD onset and a median age at onset of 77 years, compared to 63 years for those without it.
- TMEM106B-rs3173615 is identified as a genetic modifier that could optimize risk stratification for FTD in clinical practice.