Irisin-integrin αV/β5 coupling of α-synuclein phagocytosis and clearance - PubMed
3 hours ago
- #Parkinson's Disease
- #Neuroprotection
- #Exercise
- Aerobic exercise increases circulating irisin levels and reduces serum α-synuclein, improving cognitive performance in Parkinson's disease patients.
- Irisin signals through integrin αV/β5 to enhance microglial phagocytosis and clearance of α-synuclein, reducing its burden.
- The mechanism involves irisin activating the integrin αV/β5-FAK axis to promote α-synuclein uptake and stabilizing HMGB1 to facilitate autophagy-lysosome degradation.
- This dual-module mechanism couples phagocytic uptake with efficient degradation, potentially ameliorating Parkinson's disease-associated cognitive impairment.