B7-H3 membranous expression correlates with histological grading in a two-center cohort of 133 pre-treatment bone and soft tissue sarcoma samples - PubMed
3 hours ago
- #Sarcoma
- #B7-H3
- #Histological Grading
- B7-H3 targeted therapies are emerging as a promising treatment option for solid tumors.
- The study systematically analyzed B7-H3 membranous expression in 133 untreated bone and soft tissue sarcoma samples across various subtypes.
- B7-H3 was broadly expressed (97%) in sarcomas, with 45% showing low, 33% intermediate, and 19% high expression levels.
- Highest expression was found in pleomorphic liposarcoma, osteosarcoma, and angiosarcoma, while lowest in myxoid/well-differentiated liposarcoma and chondrosarcoma.
- B7-H3 expression significantly correlated with histological grading, predicting event-free survival but not overall survival.
- The findings support B7-H3 as a promising treatment target, especially in high-grade sarcomas.