Chromosome segregation synchrony in S. pombe is noise limited and arises without positive feedback - PubMed
3 days ago
- #Stochastic modeling
- #Anaphase
- #Chromosome segregation
- Anaphase in fission yeast ensures faithful genome inheritance through abrupt and synchronous sister chromatid separation.
- Chromosome segregation synchrony relies on rapid degradation of securin, a separase inhibitor, and does not require separase-mediated positive feedback.
- Stochastic modeling shows that anaphase synchrony is noise-limited due to small-number effects, constraining its temporal precision.