African swine fever virus I10L protein inhibits autolysosome formation by disrupting RAB7-HOPS complex-dependent SNARE complex assembly - PubMed
2 hours ago
- #Autophagy
- #Host-Pathogen Interaction
- #Viral Pathogenesis
- The African swine fever virus (ASFV) I10L protein inhibits autophagy by blocking autophagosome-lysosome fusion.
- I10L interacts with RAB7, preventing its binding to VPS39 of the HOPS complex, disrupting SNARE complex assembly.
- ASFV infection leads to autophagosome accumulation, while I10L deletion reverses this and reduces viral replication.
- This mechanism reveals a viral strategy to evade lysosomal degradation, offering potential therapeutic targets.