Loss of SMARCAD1 Mitigates Tauopathy - PubMed
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- #neurodegeneration
- #SMARCAD1
- #tauopathy
- The study identifies SMARCAD1 (C. elegans homolog smrd-1) as a modifier of tauopathy, with loss of function rescuing neuronal dysfunction and neurodegeneration.
- Loss of smrd-1/SMARCAD1 reduces phosphorylated and total tau levels by lowering tau mRNA transcripts in C. elegans and human HEK-tau cells.
- Rescue of tau-mediated neurodegeneration involves a tau mRNA-lowering mechanism and changes in chromatin conformation, including correction of abnormal H3K9me3 methylation.
- Human postmortem Alzheimer's disease brain tissue shows SMARCAD1 depletion in some cases, correlating with MSUT2 depletion, suggesting potential relevance to human pathology.