ATAD3 megadalton complex in Plasmodium falciparum is essential for mitochondrial and cellular viability - PubMed
3 hours ago
- #malaria
- #drug target
- #mitochondria
- The ATAD3 megadalton complex in Plasmodium falciparum is essential for parasite survival.
- It plays a critical role in multiple mitochondrial processes including RNA stability, membrane potential, ultrastructure, and protein import.
- PF3D7_0707400 is identified as an ATAD3A homolog, marking the first characterization of ATAD3A in unicellular organisms.
- The study expands understanding of apicomplexan mitochondrial biology and identifies a potential new antimalarial drug target.