Syndrome-specific vulnerability of neuronal and glial 4-repeat frontotemporal lobar degeneration-tau - PubMed
3 hours ago
- #tau pathology
- #4R-tauopathies
- #frontotemporal dementia
- CBD and PSP are the main 4R-tauopathies in frontotemporal lobar degeneration, linked to clinical syndromes like PPA and bvFTD.
- The study found that PPA cases showed left-lateralized tau pathology, with the highest burden in the anterior temporal lobe.
- In bvFTD, tau pathology was more symmetric or rightward, with peak burden in the middle frontal gyrus.
- CBD exhibited greater neuronal tau pathology, while PSP had greater glial tau pathology, forming a double-dissociation in neocortical regions.
- Hippocampal regions, particularly CA1, had higher neuronal tau burden than neocortex across both syndromes, with the dentate gyrus showing greater burden in CBD.
- Inclusion-to-neuron analysis revealed disproportionately higher tau burden in the dentate gyrus compared to neocortex, especially in CBD cases.