Theaflavin protects against ischemic stroke by inhibiting PLA2G4C-driven lipid remodeling and ferroptosis - PubMed
3 days ago
- #neuroprotection
- #ferroptosis
- #ischemic stroke
- Theaflavin protects against ischemic stroke by inhibiting PLA2G4C-driven lipid remodeling and ferroptosis.
- PLA2G4C is upregulated in ischemic brain tissue and promotes ferroptosis through PE-AA accumulation.
- Theaflavin binds directly to PLA2G4C with high affinity, reducing its activity and PE-AA content, thus attenuating lipid peroxidation and improving neuronal survival.