Non-HDL-to-HDL cholesterol ratio predicts incident T2DM and CHD in non-alcoholic fatty liver disease: evidence from a large clinical cohort and NHANES - PubMed
2 hours ago
- #NAFLD
- #NHHR
- #T2DM risk prediction
- The study investigates the Non-HDL-to-HDL Cholesterol Ratio (NHHR) as a predictor for type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD) in patients with non-alcoholic fatty liver disease (NAFLD).
- Using a large clinical cohort of 13,741 NAFLD patients and validation with the NHANES cohort (5,789 individuals), higher NHHR was strongly and independently associated with increased T2DM risk.
- A nonlinear dose-response relationship was found for T2DM, with significantly higher odds (67% increase) in the highest NHHR quartile compared to the lowest.
- Mediation analysis revealed that fasting glucose accounted for over half of the association between NHHR and T2DM, highlighting the role of glucose metabolism.
- The association between NHHR and CHD was weaker and inconsistent across cohorts, indicating limited predictive value for cardiovascular outcomes in NAFLD patients.
- The findings suggest NHHR is a simple, accessible lipid marker useful for early risk stratification and personalized prevention of T2DM in NAFLD.