A new hope: locus coeruleus-norepinephrine system at the nexus of neuropsychiatric symptoms - PubMed
3 hours ago
- #Locus Coeruleus
- #Alzheimer's Disease
- #Neuropsychiatric Symptoms
- Neuropsychiatric symptoms like anxiety and depression often appear early in Alzheimer's disease, before cognitive decline.
- Hyperactivity of the locus coeruleus-norepinephrine (LC-NE) system is implicated in driving these symptoms.
- LC-NE circuits involving brain regions such as the amygdala and prefrontal cortex contribute to psychiatric disturbances.
- Advances in neuroimaging allow in vivo tracking of LC-NE function for early detection of dysfunction.
- Targeted interventions to restore LC-NE tone could reduce symptom burden and enhance therapy efficacy in Alzheimer's.