Comparison of safety and immunogenicity between high-dose and low-dose quadrivalent influenza vaccines in children aged 6-35 months in China: A randomized, double-blind clinical study - PubMed
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- #influenza vaccine
- #clinical trial
- #pediatric immunology
- High-dose quadrivalent influenza vaccine (H-QIV) showed superior immunogenicity compared to low-dose versions in children aged 6-35 months.
- Both investigational vaccines (high-dose and low-dose) met non-inferiority criteria against a commercially available low-dose vaccine.
- H-QIV induced over 11-fold increases in antibody titers across all four influenza strains with seroprotection rates above 95%.
- Safety profiles were comparable across all vaccine groups, indicating no increased risk with high-dose vaccination.
- H-QIV may offer greater protection for young children, a high-risk group for influenza complications.