RNAs anchoring replication complex control initiation and firing of DNA replication - PubMed
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- #DNA replication
- #ANCOR RNAs
- #H2A.Z histone
- RNAs called ANCORs anchor ORC1 to H2A.Z histone variant to facilitate replication origin firing.
- ANCOR-H2A.Z interaction is essential for DNA replication in mammalian cells.
- Perturbations of ANCORs lead to abnormal replication patterns and loss of H2A.Z at origins.
- Study describes a new RNA-mediated mechanism for generating active replication origins.
- Findings suggest strategies to modulate replication origins locally and globally with biomedical potential.